Steroids for Chronic Back Pain Relief

Steroids, such as prednisone and other oral steroids are often used to manage chronic back pain when more conservative treatments—like rest, exercise, and over the counter (OTC) treatments—don’t work. Corticosteroids can also be injected into the inflamed area to alleviate the pain and swelling.

With chronic back pain, your usual activities and exercises can fuel chronic inflammation by constantly irritating the affected area.

Man with back pain.
Laura Porter / Verywell 

When the back pain runs down one leg, the condition is often referred to as sciatica, and it occurs due to irritation and inflammation of the spinal nerve root. A steroid injection (spinal epidural) for the treatment of back pain is among the most common interventions for back pain caused by irritated spinal nerve roots. 

How Do Corticosteroids Work?

Inflammation is produced by the immune system to help fight infections and heal damage, but it can be harmful in some situations. Corticosteroids block the damaging effects of inflammation through several mechanisms.

Corticosteroids inhibit the production of prostaglandins, as well as other chemicals. Steroids simulate the hormone cortisol, which your body produces naturally in the adrenal glands (small glands that sit on top of each kidney). Cortisol has many actions, including suppression of the immune system.

Severe or chronic inflammation can harm your body’s tissues, even to the point of causing more damage than the initial injury that triggered the inflammation in the first place.

Conditions Treated With Corticosteroids

Corticosteroids are often used to help manage nerve root pain caused by a herniated disc, spinal stenosis, rheumatoid arthritis flare-ups, and other conditions. 

Spinal stenosis, a chronic condition, can be caused by arthritis. The spinal cord lies inside the spine, which is a long tube-like structure formed of bone. And the spinal nerve roots normally pass through the foramen (tunnel-like openings in the bone throughout the length of the spine). The spine or the foramen can narrow due to bone spurs or other growths. When the spurs and bone growths come into contact with the nerves, irritation, pain, and/or other symptoms may result. 

Nerve route irritation is also a symptom of a herniated disc and degenerative disc disease; spinal epidurals are commonly given for these conditions, as well.

Safety and Effectiveness

Most of the time, an injection of steroid medication into your spine is safe, and in the short term, may be an effective way to relieve your pain. However, side effects are possible and can include:

  • Increase in pain
  • Severe headache
  • Muscle weakness
  • Paraesthesia (burning or tingling sensation)
  • Fainting
  • Numbness
  • Dizziness
  • Seizures
  • Vision changes or vision loss
  • Flushing in your face and chest
  • Temporary increase in body temperature
  • Problems sleeping
  • Water retention

Serious complications are rare and can include:

  • Allergic reaction
  • Infection
  • Bleeding
  • Nerve damage
  • Paralysis
  • Stroke
  • Death

By the way, don’t let the term “steroids” mislead you; corticosteroids are not the same drug many elite athletes take to improve their game.

5 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. Pountos I, Panteli M, Walters G, Bush D, Giannoudis PV. Safety of epidural corticosteroid injectionsDrugs R D. 2016;16(1):19–34. doi:10.1007/s40268-015-0119-3

  2. Williams DM. Clinical pharmacology of corticosteroids. Respir Care. 2018;63(6):655-670. doi:10.4187/respcare.06314

  3. American College of Rheumatology. Spinal stenosis.

  4. Food and Drug Administration. FDA Drug Safety Communication: FDA requires label changes to warn of rare but serious neurologic problems after epidural corticosteroid injections for pain.

  5. Johns Hopkins Medicine. Epidural corticosteroid injections.

By Anne Asher, CPT
Anne Asher, ACE-certified personal trainer, health coach, and orthopedic exercise specialist, is a back and neck pain expert.